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307.1 Anorexia Nervosa - Associated laboratory findings

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Although some individuals with Anorexia Nervosa exhibit no laboratory abnormalities, the semistarvation characteristic of this disorder can affect most major organ systems and produce a variety of disturbances. The induced vomiting and abuse of laxatives, diuretics, and enemas can also cause

a number of disturbances leading to abnormal laboratory findings.

Hematology: Leukopenia and mild anemia are common; thrombocytopenia occurs rarely.

Chemistry: Dehydration may be reflected by an elevated blood urea nitrogen (BUN). Hypercholesterolemia is common. Liver function tests may be elevated. Hypomagnesemia, hypozincemia, hypophosphatemia, and hyperamylasemia are occasionally found. Induced vomiting may lead to metabolic alkalosis (elevated serum bicarbonate), hypochloremia, and hypokalemia, and laxative abuse may cause a metabolic acidosis. Serum thyroxine (T) levels are usually in the low-normal range; triiodothyronine (T) levels are decreased. Hyperadrenocorticism and abnormal responsiveness to a variety of neuroendocrine challenges are common.

In females, low serum estrogen levels are present, whereas males have low levels of serum testosterone. There is a regression of the hypothalamic-pituitary-gonadalaxis in both sexes in that the 24-hour pattern of secretion of luteinizing hormone (LH) resembles that normally seen in prepubertal or pubertal individuals.

Electrocardiography: Sinus bradycardia and, rarely, arrhythmias are observed.

Electroencephalography: Diffuse abnormalities, reflecting a metabolicencephalopathy, may result from significant fluid and electrolyte disturbances.

Brain imaging: An increase in the ventricular-brain ratio secondary to starvation is often seen.

Resting energy expenditure: This is often significantly reduced.

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JoannaPoppink Healing Your Hungry Heart: Recovering from Your Eating Disorder by Joanna Pop... https://t.co/LbA0F7Hkji via @amazon
40mreplyretweetfavorite
JoannaPoppink Meet the man who disarmed the Waffle House shooter. James Shaw, 29, was unarmed as he rushed the shooter, disarmed… https://t.co/6GpFIuXHsj
44mreplyretweetfavorite
JoannaPoppink RT @davidhogg111: So only a good guy with a gun can stop a bad guy with a gun? @NRA 🧐 https://t.co/a61hDQrWyD
48mreplyretweetfavorite
JoannaPoppink RT @Shareblue: Rick Scott to headline gun raffle 3 months after Parkland shooting https://t.co/cWU44dhMDS
48mreplyretweetfavorite
JoannaPoppink RT @insideclimate: This treaty has been called an "unsung hero" in the fight against air pollution and climate change. It may be unknown…
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